Biophysical models of epileptic networks
Category: Current
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Epileptic seizures are events that overtake entire brain networks. How seizures are triggered, how they spread and how they eventually terminate is poorly understood. In recent years, a number of epilepsy mutations have been identified and some of these have been introduced into mice thereby creating experimental models of human epilepsy. This gives us an unprecedented opportunity to understand how brains become epileptic. Part of this process will require building detailed biophysical models of brain networks, such as hippocampus, cortex or thalamus to link biophysical deficits at the molecular level to macroscopic behaviour at the network level. The project requires significant programming to build data import tools and for interaction with the simulation environment. The candidate will interact closely with experimental biologists, engineers and theoretical neuroscientists.
