Chris Reid

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Christopher A. Reid PhD
Understanding neuronal dysfunction in epilepsy
Senior Research Officer

Fellowships:

RD Wright Fellowship (2008) -Competitive Melbourne University Research Fellowship

Molly Foundation (Australian Epilepsy Society, 2007)-The inaugural fellowship designed to support basic epilepsy researchNHMRC

Howard Florey Fellowship (2002): Synaptic Plasticity in the Central Nervous System

Royal Society Howard Florey Fellowship (1999-2001): Synaptic Plasticity in the Central Nervous System

Wellcome Trust Travelling Fellowship (1998): Optical Quantal Analysis of Synaptic Plasticity in the Hippocampus

Major Grants:

NHMRC project grant # 454655 (2007-2009): Altered HCN channel expression and function in acquired epilepsy, C. A. Reid and S. Petrou, $263 000

NHMRC project grant # 400106 (2006-2008): Neuropeptide and Absence Seizures M. Morris, T. O’Brien and C. A. Reid, $377 625

Australian Research Council (ARC # DP0449696) Discovery Project Grant (2004-2006): Calcium signaling in neurons of the central nervous system;D. A. Williams and C.A. Reid, $285 000

NHMRC project grant # 236801 (2003-2005): Mechanisms underlying short- and long-term plasticity at the mossy fibre to CA3 pyramidal neuron synapse in the hippocampus; C.A. Reid, $260 000

Selected Publications: (see all recent publications below)

Reid, C.A., Berkovic, S.F. and Petrou S. Mechanisms of Inherited epilepsies Prog Neurobiol, 2008 in press accepted 10/08 [IF= 10.5, listed in top 20 most popular download for ion channels. This review covers a lot of ground on a very active research area]

Chiu, C., C.A. Reid (equal first), H.O. Tan, P.J. Davies, F.N. Single, I. Koukoulas, S.F. Berkovic, S.S. Tan, R. Sprengel, M.V. Jones, and S. Petrou, Developmental impact of a familial GABAA receptor epilepsy mutation. Ann Neurol, 2008. 64(3): p. 284-93. [IF= 8.8. This article provides evidence for a concept that has been around for some time, but for which there is little experimental evidence. This has potential therapeutic implications in that we can possibly treat epilepsy before seizure presentation. This journal is highly regarded in clinical neurological circles.]

Reid, C.A.(corresponding), S. Xu and D.A. Williams, Spontaneous release from mossy fiber terminals inhibits Ni2+-sensitive T-type Ca2+ channels of CA3 pyramidal neurons in the rat organotypic hippocampal slice. Hippocampus, 2008. 18(7): p. 623-30. [IF= 5.8 This article explores a new molecular interaction at a specialised synapse. It may represent a novel mode of reducing hippocampal excitability.]

Reid, C.A., D.B. Dixon, M. Takahashi, T.V. Bliss and A. Fine, Optical quantal analysis indicates that long-term potentiation at single hippocampal mossy fiber synapses is expressed through increased release probability, recruitment of new release sites, and activation of silent synapses. J Neurosci, 2004. 24(14): p. 3618-26. [IF= 7.5, Citations> 30. This paper addresses the issue of LTP expression using the technically demanding combination of electrophysiology and imaging. It is the first time visualisation of an un-silenced synapse has been recorded]

Reid, C.A., R. Fabian-Fine and A. Fine, Postsynaptic calcium transients evoked by activation of individual hippocampal mossy fiber synapses. J Neurosci, 2001. 21(7): p. 2206-14. [IF= 7.5, Citations> 30. This paper addresses the basic function of spines on neurons. The real-time function of these small compartments is only accessible using the technically demanding combination of electrophysiology and imaging. Here we show that Ca2+ compartmentalisation is common between different spine types suggesting a common function]

Reid, C.A. (corresponding), J.M. Bekkers and J.D. Clements, Presynaptic Ca2+ channels: a functional patchwork. Trends Neurosci, 2003. 26(12): p. 683-7. [IF= 12.5, Citations> 55. Highly regarded review that speculates on the role of a non-uniform distribution of Ca2+ channels across presynaptic terminals. This draws on two highly cited research articles published in J Neurosci- see below]

Emptage, N.J., C.A. Reid and A. Fine, Calcium stores in hippocampal synaptic boutons mediate short-term plasticity, store-operated Ca2+ entry, and spontaneous transmitter release. Neuron, 2001. 29(1): p. 197-208. [IF= 13.4, Citations>170. This paper presents data that proposes that internal Ca2+ stores are important modulators of transmitter release. This presented a change in thinking about how terminals work]

Reid, C.A. and J.D. Clements, Postsynaptic expression of long-term potentiation in the rat dentate gyrus demonstrated by variance-mean analysis. J Physiol, 1999. 518 (Pt 1): p. 121-30. [IF= 4.4, Citations> 35. Here we develop a new electrophysiological method for determining the locus of LTP expression]

Reid, C.A., J.M. Bekkers and J.D. Clements, N- and P/Q-type Ca2+ channels mediate transmitter release with a similar cooperativity at rat hippocampal autapses. J Neurosci, 1998. 18(8): p. 2849-55. [IF= 7.5, Citations> 50, see TiNS article above]

Reid, C.A., J.D. Clements and J.M. Bekkers, Nonuniform distribution of Ca2+ channel subtypes on presynaptic terminals of excitatory synapses in hippocampal cultures. J Neurosci, 1997. 17(8): p. 2738-45. [IF= 7.5, Citations> 50, see TiNS article above]

Recent publications (2004 - )

Reid, C.A., Berkovic, S.F. and Petrou S. Mechanisms of Inherited epilepsies Prog Neurobiol, 2008 in press accepted 10/08 [IF= 10.5]- top 20 down-loaded papers in Oct 2008 (Ion Channels News Letter)

Kim L Powell, Stuart M Cain, Caroline N, Shreerang Sirdesai, Laurence S David, Mervyn Kyi, Esperanza Garcia, John R Tyson^, Christopher A Reid, Melanie Bahlo, Simon J Foote, Terrance P Snutch, Terence J O’Brien. J Neurosci [IF= 7.5] (accepted 11/08)

Reid, C.A. (corresponding), B.E. Adams, D. Myers, T.J. O'Brien and D.A. Williams, Sub region-specific modulation of synchronous neuronal burst firing after a kainic acid insult in organotypic hippocampal cultures. BMC Neurosci, 2008. 9: p. 59. [IF= 3]

Tan, H.O., C.A. Reid (equal first), C. Chiu, M.V. Jones and S. Petrou, Increased thalamic inhibition in the absence seizure prone DBA/2J mouse. Epilepsia, 2008. 49(5): p. 921-5. [IF= 3.6]

Powell, K.L., C. Ng, T.J. O'Brien, S.H. Xu, D.A. Williams, S.J. Foote, and C.A. Reid, Decreases in HCN mRNA expression in the hippocampus after kindling and status epilepticus in adult rats. Epilepsia, 2008. [IF= 3.6]

Powell, K.L., M. Kyi, C.A. Reid, L. Paradiso, G.M. D'Abaco, A.H. Kaye, S.J. Foote, and T.J. O'Brien, Genetic absence epilepsy rats from Strasbourg have increased corticothalamic expression of stargazin. Neurobiol Dis, 2008. 31(2): p. 261-5. [IF= 4.4]

Zheng, T., A.L. Clarke, M.J. Morris, C.A. Reid, S. Petrou and T.J. O'Brien, Oxcarbazepine, not its active metabolite, potentiates GABA(A) activation and aggravates absence seizures. Epilepsia, 2008. [IF= 3.6]

Tan, H.O., C.A. Reid, F.N. Single, P.J. Davies, C. Chiu, S. Murphy, A.L. Clarke, L. Dibbens, H. Krestel, J.C. Mulley, M.V. Jones, P.H. Seeburg, B. Sakmann, S.F. Berkovic, R. Sprengel, and S. Petrou, Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy. Proc Natl Acad Sci U S A, 2007. 104(44): p. 17536-41. [IF= 9.6]

Reid, C.A., H.A. Coleman, D.I. Finkelstein, M.K. Horne and J. Drago, Null mutation of the alpha4 nicotinic receptor subunit increases the propensity of muscarinic-mediated neuronal bursting in mouse hippocampal slices. Neuropharmacology, 2006. 51(3): p. 587-96. [IF= 3.2]

Liu, L., T. Zheng, M.J. Morris, C. Wallengren, A.L. Clarke, C.A. Reid, S. Petrou, and T.J. O'Brien, The mechanism of carbamazepine aggravation of absence seizures. J Pharmacol Exp Ther, 2006. 319(2): p. 790-8. [IF= 4.4]

Monif, M., M.L. Smart, C.A. Reid and D.A. Williams, Development of low-affinity, membrane-targeted Ca2+ sensors suitable for measuring presynaptic Ca2+. Clin Exp Pharmacol Physiol, 2004. 31(12): p. 885-9. [IF= 2]

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