Successful grant applications!

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Published Date Written by Lynley Cordeiro

The Ion Channels and Diseases Laboratory have been very successful in this year’s funding outcomes.

 

ARC Discovery Projects for funding commencing in 2012:

 

Approved Project Title: Genetic dissection of functional-structural connectivity using optogenetic fMRI and dMRI

Tractography

Petrou, A/Prof Steven; Calamante, A/Prof Fernando; Reid, Dr Christopher A

 

Project Summary

The project will map the connectivity pattern of genetically defined neurons in mouse brain by combining state of the art

molecular and neuroscience imaging technology. The outcome will be a significant step toward building a complete

functional and structural mapping resource, with application for examining dysfunction in neurological disease models.

 

Approved Project Title: Brain sodium channel: functional role of developmentally regulated alternative splicing

Petrou, A/Prof Steven; Reid, Dr Christopher A

 

Project Summary

This project will identify the roles of neonatal and adult forms of a sodium channel in the function of neurons in the

developing brain. Sodium channels are vital for brain function and this study will improve our understanding of the

function of healthy brain as well as of underlying mechanisms of some neurological disorders.

 

 

NHMRC Project Grant for funding commencing in 2012.

 

Approved Project Title: Neuroanatomical correlates of susceptibility in a model of genetic epilepsy.

Dr Verena Wimmer

 

First paper of the year

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Published Date Written by Evan Thomas

Chris's review has come out:

Mechanisms of human inherited epilepsies. Reid CA, Berkovic SF, Petrou S. Prog Neurobiol. 2009 87(1):41-57.

Pubmed.

Last paper of the year

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Published Date Written by Evan Thomas

An editorial by Evan and Steve has come out, complete with a grammitical error in the title courtesy of the journal type setters.

Case for realistic modeling in understanding seizures. Thomas EA, Petrou S. Expert Rev Neurother. 2008 8(12):1771-3.

Pubmed.

Congratulations to Chris on his recent flood of papers!

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Published Date Written by Steven Petrou
 
Reid CA, Berkovic SF, Petrou S. Mechanisms of human inherited epilepsies. Prog Neurobiol. 2008 Oct 5. [Epub ahead of print]

Chiu C, Reid CA, Tan HO, Davies PJ, Single FN, Koukoulas I, Berkovic SF, Tan SS, Sprengel R, Jones MV, Petrou S. Developmental impact of a familial GABAA receptor epilepsy mutation.Ann Neurol. 2008 Sep;64(3):284-93.

Zheng T, Clarke AL, Morris MJ, Reid CA, Petrou S, O'Brien TJ. Oxcarbazepine, not its active metabolite, potentiates GABA(A) activation and aggravates absence seizures.Epilepsia. 2008 Aug 19.

Reid CA, Adams BE, Myers D, O'Brien TJ, Williams DA. Sub region-specific modulation of synchronous neuronal burst firing after a kainic acid insult in organotypic hippocampal cultures.BMC Neurosci. 2008 Jul 2;9:59.

Powell KL, Kyi M, Reid CA, Paradiso L, D'Abaco GM, Kaye AH, Foote SJ, O'Brien TJ. Genetic absence epilepsy rats from Strasbourg have increased corticothalamic expression of stargazin.Neurobiol Dis. 2008 Aug;31(2):261-5. 

Powell KL, Ng C, O'Brien TJ, Xu SH, Williams DA, Foote SJ, Reid CA. Decreases in HCN mRNA expression in the hippocampus after kindling and status epilepticus in adult rats.Epilepsia. 2008 Oct;49(10):1686-95.

Reid CA, Xu S, Williams DA. Spontaneous release from mossy fiber terminals inhibits Ni2+-sensitive T-type Ca2+ channels of CA3 pyramidal neurons in the rat organotypic hippocampal slice. Hippocampus. 2008;18(7):623-30.

Well done Arthur and Frank!!

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Published Date Written by Steven Petrou
Congratulations on the nomination of your sodium channel modeling projects for the College of Biomedical Engineering (Engineers Australia, Victoria Division) Annual Undergraduate Student Presentations.  
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